Current Studies

TARGET: 1,575

TILT: Time-Lapse Imaging Trial - A pragmatic, multi-centre, three-arm randomised controlled trial to assess the clinical effectiveness and safety of time lapse imaging in in-vitro fertilisation treatment.

Background: 

Many couples experience problems becoming pregnant. They often undergo procedures such as in-vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI) where an embryo is implanted into the womb to help them become pregnant, however this does not always work. Although the number of women having IVF/ICSI is increasing, the success rates are less than ideal and have remained similar over the last few years.

The success rate of IVF/ICSI depends on the ability to select the best embryo for transfer, and transferring more than one embryo to increase the likelihood of success can result in multiple births. Part of the problem is there is a lack of evidence regarding the best method to choose which embryo to use. National guidelines and fertility experts recommend further research into methods to improve embryo selection. Time lapse imaging (TLI) is a newer technology available in IVF/ICSI laboratories. It is hypothesised to improve the accuracy for embryo selection from a group of available embryos. In addition, it also provides an undisturbed environment for the embryos when they are developing.

Aims:

-The primary objective of the trial is to determine if the use of TLI or undisturbed culture in IVF/ICSI treatment results in a higher live birth rate when compared to current standard methods of embryo incubation and assessment.

Study start: May 2018

Study Duration: 24 Months

Participating Sites: 

-Homerton University Hospital 

-Bath Fertility Centre 

-Princess Anne Hospital, Southampton

-St Barts Hospital

-Hammersmith Hospital

-Derriford Hospital, Plymouth

-Chinese University of Hong Kong

Recruitment Target: 1,575

http://www.isrctn.com/ISRCTN17792989

Trial Contact Details:

James Heighway
TILT Trial Coordinator
Women’s Health Research Unit 
Centre for Primary Care and Public Health
Barts and The London School of Medicine & Dentistry
Yvonne Carter Building
58 Turner Street
London
E1 2AB
Tel: +44 (0)20 7882 3272
Email: j.heighway@qmul.ac.uk

Location

Barts Centre for Women's Health Research 
Centre for Primary Care and Public Health
Blizard Institute
Barts and The London School of Medicine and Dentistry
Yvonne Carter Building
58 Turner Street
London E1 2AB

Tel: +44 (0)20 7882 2525

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