Current Studies

TARGET: 200

OMAhA: Optimising health outcomes by using Metformin to reduce risk of diabetes After pregnancy: a feasibility study for a randomised, blinded, placebo-controlled trial

Background: 

Up to 50% of women affected by Gestational Diabetes (GDM) will progress to type 2 diabetes in the next five years. The proportion of women diagnosed with GDM is on the increase, and if GDM or type 2 diabetes continue to go undiagnosed and untreated, there is an increased risk of a number of maternal and fetal complications.

Current guidelines recommend that women diagnosed with GDM are followed up after birth, however only a fifth of all women with GDM undergo postnatal screening for type 2 diabetes. Metformin is an established treatment for type 2 diabetes during pregnancy and in the postnatal period, and for GDM. It is a safe, cheap and easy medicine to administer, and importantly, has been effective in reducing the rate of type 2 diabetes in general populations at risk of type 2 diabetes. 

Metformin has not previously been used by postnatal women, with a diagnosis of gestational diabetes. Previous research shows the promising role of metformin in reducing the risk of type 2 diabetes by up to 50%, with a potential benefit persisting after 10 years. 
 

Aims:

In order to evaluate the effectiveness of administering metformin to women in the postnatal period, to reduce the risk of type 2 diabetes, the current study will ask the following main questions:

- What are the rates of recruitment and randomisation?

- What proportion of those randomised complete the study?

- What are the reasons for participation and non-participation?

 

Study start: October 2018

Study Duration: 18 Months

Participating Sites: 

- The Royal London Hospital
- Whipps Cross University Hospital
- Newham University Hospital

Recruitment Target: 200

http://www.isrctn.com/ISRCTN20930880

Information on how we use participant data

Trial Contact Details:

 

Zoe Drymoussi, PhD
BARC Trial Coordinator

Barts Research Centre for Women’s Health

Institute of Population Health Sciences
Barts and The London School of Medicine & Dentistry

Queen Mary University of London
Yvonne Carter Building
58 Turner Street, London E1 2AB

Tel: +4420 7882 6692 

Newsletters:

AUG 2019

MAR 2020