Current Studies


OMAhA: Optimising health outcomes by using Metformin to reduce risk of diabetes After pregnancy: a feasibility study for a randomised, blinded, placebo-controlled trial


Up to 50% of women affected by Gestational Diabetes (GDM) will progress to type 2 diabetes in the next five years. The proportion of women diagnosed with GDM is on the increase, and if GDM or type 2 diabetes continue to go undiagnosed and untreated, there is an increased risk of a number of maternal and fetal complications.

Current guidelines recommend that women diagnosed with GDM are followed up after birth, however only a fifth of all women with GDM undergo postnatal screening for type 2 diabetes. Metformin is an established treatment for type 2 diabetes during pregnancy and in the postnatal period, and for GDM. It is a safe, cheap and easy medicine to administer, and importantly, has been effective in reducing the rate of type 2 diabetes in general populations at risk of type 2 diabetes. 

Metformin has not previously been used by postnatal women, with a diagnosis of gestational diabetes. Previous research shows the promising role of metformin in reducing the risk of type 2 diabetes by up to 50%, with a potential benefit persisting after 10 years. 


In order to evaluate the effectiveness of administering metformin to women in the postnatal period, to reduce the risk of type 2 diabetes, the current study will ask the following main questions:

- What are the rates of recruitment and randomisation?

- What proportion of those randomised complete the study?

- What are the reasons for participation and non-participation?


Study start: October 2018

Study Duration: 18 Months

Participating Sites: 

- The Royal London Hospital
- Whipps Cross University Hospital
- Newham University Hospital

Recruitment Target: 200

Trial Contact Details:


Zoe Drymoussi, PhD
BARC Trial Coordinator
Barts Research Centre for Women’s Health
Women’s Health Research Unit | Queen Mary University of London
58 Turner Street | London E1 2AB

Tel: +4420 7882 6692 

Participant Newsletters:

AUG 2019


Barts Centre for Women's Health Research 
Institute of Population Health Sciences
Barts and The London School of Medicine and Dentistry

Queen Mary University of London
Yvonne Carter Building
58 Turner Street
London E1 2AB

Tel: +44 (0)20 7882 2525

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